The Dodgers completed their 10-game homestand at 4-6 and fell to 6-9 at Dodger Stadium this season, winning only one of its five home series.
Ryu kept the game manageable for a while as the offense sputtered, down 3-1 through five innings. But he was unable to record an out in the sixth inning. After Justin Morneau doubled and Nolan Arenado singled to put two runners on, Josh Rutledge ripped a three-run home run to the left field pavilion to blow open the game.
In 13 innings at home this season, Ryu has allowed 26 hits, 16 runs (14 earned), and five walks, with eight strikeouts.
In 26 innings on the road this year, Ryu has allowed 11 hits, no runs and six walks, with 23 strikeouts.
The Dodgers scored first, with a Dee Gordon bunt single and stolen base, and a two-out single by Adrian Gonzalez. It was the 13th different game in which Gonzalez has driven in a run this season, tied for third most in the majors.
But that lead was short lived, though both teams had similar opportunities in the second inning. In both halves of the inning, each team's leadoff batter came up with two runners on base and two outs. Charlie Blackmon was hit by a pitch to load the bases, followed by a two-run single from Brandon Barnes for a 2-1 Colorado lead.
In the bottom of the inning, Gordon was up with two runners on and two out but grounded to shortstop to end the frame.
Much like Saturday night with Paul Maholm snapping a seven-game losing streak to the Rockies, Jorge De La Rosa has turned things around against the Dodgers. He began his career winless in 10 starts against the Dodgers, with an 0-8 record and a devilish 6.66 ERA. But dating back to 2013 the left-hander has beaten the Dodgers three straight times.
De La Rosa allowed just one run on four hits in his seven innings on Sunday, with two walks and three strikeouts. He retired 10 in a row at one point into the sixth inning.
After Ryu, the mound was a low-leverage workshop for Dodgers former closers. Brandon League struck out two and retired all six batters he faced in his two innings, then Brian Wilson pitched a scoreless frame in the eighth, though he did allow a double to Morneau. It marked the first time this season Wilson has pitched on consecutive days.
Hanley Ramirez, who didn't start after bruising his right thumb on Saturday night, pinch hit in the ninth inning. He reached on an infield single.
Rockies third baseman and 2013 National League Gold Glove Award winner Arenado made a number of fantastic plays during the weekend series, but perhaps none as impressive as robbing Scott Van Slyke of a double in the fourth inning.
The Dodgers will fly to Minnesota on their off day Monday, and will begin their nine-game road trip on Tuesday night at Target Field. Zack Greinke starts the opener of the three-game series, against Kyle Gibson for the Twins.
Home run: Josh Rutledge (1)
WP - Jorge De La Rosa (2-3): 7 IP, 4 hits, 1 run, 2 walks, 3 strikeouts
LP - Hyun-jin Ryu (3-2): 5+ IP, 9 hits, 6 runs, 3 strikeouts