Puig was originally scheduled to be the designated hitter against Cleveland, batting third. But now those duties will shift to catcher Yasmani Grandal.
"It actually worked out because Grandal wanted more at-bats, so we'll give him those at-bats," manager Don Mattingly said.
Puig is 3-for-14 (.214) with a home run and two walks in six Cactus League games this spring.
Brett Anderson starts for the Dodger, making his second start.
Bruce Chen starts for the Indians, potentially his 11th major league team. Carlos Carrasco was originally slated to start for Cleveland, but was scratched due to illness. Old friend Jerry Sands, a non-roster invitee to Indians camp, starts at first base and bats fifth for Cleveland.
In other sickness news, Dodgers third base coach Lorenzo Bundy missed Friday's game with an illness, but is back and feeling better Saturday. Double-A Tulsa manager Razoe Shines coached third base for the Dodgers on Friday against the Reds in Bundy's absence.