The Dodgers try for their first win in five tries against the Giants in San Francisco this season, with Brett Anderson and Tim Lincecum each making their third start against the other team on Wednesday night.
Anderson has not fared well in either of his two starts against the Giants this season, pulled after four innings in San Francisco on April 21, then chased in the fifth inning at Dodger Stadium on April 27.
The ground ball specialist has defensive stalwart Juan Uribe at third base for the eighth time in eight starts this season.
Alex Guerrero, who started at third base on Tuesday night, starts in left field on Wednesday. He is 6-for-9 (.667) with two home runs and a double at AT&T Park this season, while Uribe is 4-for-9 (.444) with a double at his former home.
The rest of the Dodgers are hitting .149 (17-for-114) with one double and one home run in San Francisco this season.
Lincecum has faced no batter in baseball more than Adrian Gonzalez, who is 17-for-64 (.266) with five walks and a sacrifice fly against him. But Gonzalez in 70 plate appearances against Lincecum has been held without an extra-base hit.
Uribe is 10-for-33 (.303) with three home runs, two doubles and two walks against Lincecum in his career, including 2-for-3 with a double and a walk this season.