Curtis Granderson, who bats leadoff and plays right field, and pitcher Jacob deGrom, are the only two left-handed hitters in the Mets lineup in the opener of a three-game weekend series.
New York also has switch-hitters Asdrubal Cabrera at shortstop and Neil Walker at second base.
Yasmani Grandal, who homered on Wednesday, catches Urias in the series opener, which was to be expected since A.J. Ellis is likely catching Sunday night with Clayton Kershaw on the mound in the series finale.
Howie Kendrick, hitting .326/.375/.488 over his last 12 games, starts in left field for the Dodgers on Friday night.
Should Urias, who was 2-for-12 (.167) with two walks and five strikeouts in the minor leagues, get a hit on Friday, he would join a select group. Only nine LA Dodgers pitchers have hits in their major league debut, including Kenta Maeda, who homered on April 6 in San Diego.
The others are Nathan Eovaldi (2011), Chad Billingsley (2006), Eric Gagne (1999), Doug Rau (1972), Don Sutton (1966), Bill Singer (1964), Larry Miller (1964) and Jim Golden (1960).