Reddick, starting in right field, is batting .296/.368/.449 on the season, including .341/.408/.547 against right-handed pitching. Jon Gray, who throws a baseball with his right hand, starts for the Rockies on Tuesday.
This is the 14th time in Reddick's career he has batted cleanup, with the previous 13 coming in 2015. Reddick batted third in 62 of his 63 starts this season with Oakland.
The inclusion of Reddick into the lineup gives the Dodgers five left-handers starting on Tuesday, plus switch-hitter Yasmani Grandal at catcher.
Justin Turner and Howie Kendrick are the only two right-handed batters among the eight starting position players for the Dodgers.
Adrian Gonzalez bats fifth for a fourth time this season. He has also started at cleanup 78 times and batted third 14 times in 2016.
Reddick joins Kendrick (2015) and Gonzalez (2012) as the last three players to bat cleanup in their first game with the Dodgers.
Colorado roster move
This series will not feature a battle of exceptional rookie shortstops, as the Rockies placed Trevor Story on the disabled list with a torn ulnar collateral ligament in his left thumb. Old friend Rafael Ynoa was recalled from Triple-A Albuquerque.
Daniel Descalso starts at shortstop for the Rockies on Tuesday.